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. 2020 Nov 26;13(1):750–768. doi: 10.18632/aging.202182

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Copyright: © 2020 Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ssGESA and ESTIMATE analysis of the relationship between KRAS mutations and immune activities. (A) In ssGSEA, 30 immune-related pathways were incorporated to estimate the immune capacity of individual colon cancer samples. These gene sets were composed of immune cells and processes. The tumor purity, immune score, and stromal score are also shown in the heatmap. (B–D) Using the Mann-Whitney test, we found that the KRAS-mutated group was of lower immune and stromal score while its tumor purity was higher than the wild-type group.