Skip to main content
. 2020 Nov 30;13(1):735–749. doi: 10.18632/aging.202181

Figure 1.

Figure 1

TRIM expression was decreased in PD patients, PD mice and cells. (A) TRIM3 mRNA expression in venous blood samples of 53 patients with PD was reduced. (B and C) MPTP-HCl injection prominently decreased TRIM3 mRNA and protein expression in the mice midbrain with a time-dependent manner. (D) MPP+ treatment dramatically reduced cells viability with a dose-dependent manner. (E) MPP+ treatment significantly decreased TRIM3 protein expression in SH-SY5Y cells with a dose-dependent manner. (F) MPP+ treatment obviously reduced the number of TH positive expression dopaminergic neurons in the mice midbrain with a time-dependent manner. * P < 0.05 and ** P < 0.01 relative to Sham group or Control group.