Table 5. Univariate and multivariate analysis of factors affecting DFS of GC patients after curative surgery.
| Variables | Univariate analysis | Multivariate analysis | |||||
| HR | 95%CI | P value | HR | 95%CI | P value | ||
| Age (years old) | <0.001 | <0.001 | |||||
| < 65 | 1.00 | 1.00 | |||||
| ≥65 | 1.75 | 1.443-2.120 | 1.85 | 1.517-2.250 | |||
| Gender | 0.015 | 0.018 | |||||
| Male | 1.00 | 1.00 | |||||
| Female | 0.80 | 0.664-0.957 | 0.80 | 0.659-0.961 | |||
| Tumor location | <0.001 | 0.054 | |||||
| Upper stomach | 1.00 | 1.00 | |||||
| Middle stomach | 0.61 | 0.459-0.812 | 0.68 | 0.507-0.915 | |||
| Lower stomach | 0.74 | 0.561-0.965 | 0.84 | 0.634-1.111 | |||
| Whole stomach | 2.78 | 1.534-5.047 | 0.97 | 0.513-1.835 | |||
| Gross appearance | <0.001 | 0.004 | |||||
| Superficial type | 1.00 | 1.00 | |||||
| Bormann type 1 | 1.95 | 1.208-3.155 | 1.29 | 0.772-2.142 | |||
| Bormann type 2 | 2.00 | 1.491-2.686 | 0.90 | 0.620-1.306 | |||
| Bormann type 3 | 3.35 | 2.688-4.174 | 1.42 | 1.026-1.963 | |||
| Bormann type 4 | 5.00 | 3.572-7.006 | 1.76 | 1.134-2.737 | |||
| Lymphovascular invasion | <0.001 | 0.149 | |||||
| Absent | 1.00 | 1.00 | |||||
| Present | 2.92 | 2.404-3.556 | 1.22 | 0.931-1.602 | |||
| Lauren’s classification | 0.351 | ||||||
| Intestinal type | 1.00 | ||||||
| Diffuse type | 1.09 | 0.909-1.309 | |||||
| Adjuvant chemotherapy | <0.001 | 0.796 | |||||
| No | 1.00 | 1.00 | |||||
| Yes | 2.27 | 1.702-3.026 | 1.05 | 0.748-1.461 | |||
| Pathological T category | <0.001 | <0.001 | |||||
| T1 | 1.00 | 1.00 | |||||
| T2 | 1.34 | 0.962-1.859 | 0.90 | 0.610-1.322 | |||
| T3 | 3.32 | 2.588-4.251 | 1.50 | 1.021-2.203 | |||
| T4 | 4.67 | 3.668-5.954 | 1.95 | 1.329-2.874 | |||
| Pathological N category | <0.001 | <0.001 | |||||
| N0 | 1.00 | 1.00 | |||||
| N1 | 1.50 | 1.128-2.006 | 1.07 | 0.778-1.476 | |||
| N2 | 2.41 | 1.821-3.179 | 1.53 | 1.116-2.107 | |||
| N3 | 6.91 | 5.491-8.691 | 3.55 | 2.599-4.859 | |||
OS: overall survival; DFS: disease-free survival; bold: statistically significant.