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Structure of SRPK1-compund C02 complex is superimposed with SRPK1-ASF/SF2 complex. It is clearly seen that C02 has interrupted the complex formation by engaging Lys174 which forms critical attractive interaction with Glu170 of ASF/SF2. Lys174 is rotated almost 2-folds towards ATP binding site and is unavailable to form salt bridge interactions with Glu170 of ASF/SF2.
