Table 1. SRPK1 binding properties of the screened natural compounds and known inhibitors.

S.No.	Compounds	Residues involved in polar interactions	Residues involved in non-polar interactions	Glide e-model	Glide energy	XP GScore
1.	Compound C01 (ZINC00518605)	Leu168, His170, Tyr227	Leu86, Val94, Leu96, Val145, Phe165, Val167, Leu168, Leu220, Tyr227, Ile228 and Leu231	-72.51	-54.61	-11.31
2.	Compound C02 (ZINC02154892)	Leu168, His170, Lys174, Tyr227	Leu86, Val94, Ala107, Val145, Phe165, Val167, Leu220, Leu231, Ala496	-92.63	-60.29	-12.40
3.	Compound C03 ZINC23127139	Leu168, Asp497, His170	Val94, Lue96, Ala107, Lys109, Val145, Phe165, Val167, Leu220 Leu231, Val223, Tyr227, Ile228, Ala496	-80.70	-47.34	-12.01
4.	Compound C04 ZINC28182826	Leu168, Asn218, Asp497	Leu86, Val94, Leu96, Ala107, Lys109, Val145, Val167, Phe165, Lys215, Leu220 Val223, Ile228, Leu231, Tyr227, Ala496	-75.41	-46.37	-11.34
5.	Compound C05 ZINC62001834	Leu168, Asp497, Tyr227	Leu86, Val94, Leu96, Ala107, Leu128, Val145, Phe165, Val167, Leu220, Val223, Ile228, Leu231, Ala496, Leu498	-74.92	-47.52	-12.46
6.	Compound C06 (ZINC70666371)	Leu168, Tyr227, Asp497	Leu86, Val94, Leu96, Leu128, Val145, Phe165, Val167, Leu220, Val223, Leu231, Ala496, Leu498	-72.51	-45.24	-11.13
7.	SRPIN340 [17]	Leu168	Leu86, Ala107, Val145, Leu168, Phe165, Val167, Val223, Tyr227, Leu231	- 75.89	- 47.86	- 9.61
8.	SPHINX31 [14]	Leu168, Lys109	Leu86, Trp88, Gly89, Ser92, Val94, Ala107, Phe165, Glu166, Val167, Gly169, His170, Leu220, Ala496 and Asp497	-	-	-
9.	Compound I [14]	Leu168	Leu86, Tyr88, Gly89, Ser92, Val94, Ala107, Phe165, Glu166, Val167, Gly169, His170, Leu220, Ala496 and Asp497	-	-	-
10.	Alectinib [24]	Leu168	Arg84, Leu86, Val94, Ala107, Phe165, Val167, His170, Leu220, Val223, Tyr227, Leu231	-	-	-