Table 2. Gene Ontology (GO) (Cellular Component), GO (Biological Process), GO (Molecular Function), Kyoto Encyclopedia of Genes and Genomes (KEGG pathway), Kinase, miRNA, and transcription factor-target networks of KIAA0101 in lung adenocarcinoma (LinkedOmics).
| Enriched Category | Geneset | LeadingEdgeNum | NES | P Value | FDR |
| GO (Cellular Component) | condensed chromosome | 66 | 2.6425 | 0 | 0 |
| chromosomal region | 94 | 2.5825 | 0 | 0 | |
| mitochondrial protein complex | 152 | 2.3976 | 0 | 0 | |
| ribosome | 143 | 2.3858 | 0 | 0 | |
| spindle | 70 | 2.3837 | 0 | 0 | |
| GO (Biological_Process) | chromosome segregation | 97 | 2.6361 | 0 | 0 |
| DNA replication | 96 | 2.4830 | 0 | 0 | |
| cell cycle checkpoint | 60 | 2.3720 | 0 | 0 | |
| double-strand break repair | 61 | 2.3053 | 0 | 0 | |
| spindle organization | 44 | 2.2998 | 0 | 0 | |
| GO (Molecular_Function) | structural constituent of ribosome | 109 | 2.3582 | 0 | 0 |
| catalytic activity, acting on DNA | 69 | 2.2380 | 0 | 0 | |
| single-stranded DNA binding | 43 | 2.1594 | 0 | 0 | |
| helicase activity | 43 | 2.0895 | 0 | 0 | |
| catalytic activity, acting on RNA | 122 | 2.0460 | 0 | 0 | |
| KEGG pathway | Cell cycle | 48 | 2.4639 | 0 | 0 |
| Ribosome | 100 | 2.2904 | 0 | 0 | |
| Proteasome | 40 | 2.2761 | 0 | 0 | |
| Spliceosome | 63 | 2.2601 | 0 | 0 | |
| DNA replication | 27 | 2.1887 | 0 | 0 | |
| Kinase Target | Kinase_CDK1 | 74 | 2.3361 | 0 | 0 |
| Kinase_PLK1 | 32 | 2.3154 | 0 | 0 | |
| Kinase_AURKB | 35 | 2.1660 | 0 | 0 | |
| Kinase_CDK2 | 73 | 2.1657 | 0 | 0 | |
| Kinase_ATR | 20 | 2.0601 | 0 | 0 | |
| miRNA Target | GAGCCTG,MIR-484 | 40 | -(1.7728 | 0 | 0.025589 |
| CAGCACT,MIR-512-3P | 53 | (1.6953 | 0 | 0.029684 | |
| TTTGCAC,MIR-19A,MIR-19B | 148 | (1.7059 | 0 | 0.034546 | |
| GACAATC,MIR-219 | 60 | (1.7191 | 0 | 0.039237 | |
| CCCAGAG,MIR-326 | 58 | (1.6503 | 0 | 0.039481 | |
| Transcription Factor Target | V$E2F_Q6 | 87 | 2.2583 | 0 | 0 |
| V$E2F_Q4 | 86 | 2.2538 | 0 | 0 | |
| V$E2F4DP1_01 | 94 | 2.2226 | 0 | 0 | |
| V$E2F1_Q6 | 96 | 2.2207 | 0 | 0 | |
| V$E2F_02 | 93 | 2.1958 | 0 | 0 |
Abbreviations: Leading EdgeNum, the number of leading edge genes; FDR, false discovery rate from Benjamini and Hochberg from gene set enrichment analysis (GSEA); NES, Normalized Enrichment Score. It is generally considered that the absolute value of NES ≥ 1.0, NOM p-val ≤ 0.05, FDR q-val ≤ 0.25 are significant gene sets. The annotation was found in the Molecular Signatures Database (MSigDB) for transcription factors (TF).