Table 2. Top 10 hub proteins in PPI network based on degree.
Gene name | Degree | Betweenness | Centroid | Closeness | Bridging |
UBA52 | 75 | 23277.55 | -22 | 0.001153 | 32.12191 |
MAPK1 | 69 | 14795.83 | 9 | 0.001176 | 28.44867 |
HSPA8 | 56 | 14824.35 | -14 | 0.001145 | 56.68246 |
ACTB | 55 | 11072.69 | -23 | 0.001142 | 40.24189 |
ACLY | 52 | 14155.31 | -159 | 9.90E-04 | 35.44649 |
APP | 49 | 7938.799 | -44 | 0.001119 | 36.50353 |
ACTN1 | 49 | 5651.568 | -20 | 0.001144 | 38.92992 |
ACTN4 | 47 | 5555.22 | -22 | 0.00114 | 43.87646 |
VWF | 46 | 3615.55 | -104 | 0.001048 | 35.02035 |
TGFB1 | 41 | 8255.129 | -19 | 0.001151 | 58.37043 |
Degree, betweenness, centroid, closeness and bridging are algorithms provided by plugin Centiscape in software Cytoscape.