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. 2020 Nov 16;13(1):910–932. doi: 10.18632/aging.202202

Figure 4.

Figure 4

Tan IIA inhibits oxLDL-induced LOX-1-mediated ROS production and mitochondrial damage in macrophages. (E) Inhibition of Tan IIA on oxLDL-induced mito-ROS production in the B6 macrophages. (F) The oxLDL-induced mitochondria damage and Tan IIA inhibition on it in mouse B6 macrophages and LOX-1-KD macrophages. MitoTracker Deep Red for health mitochondria staining and MitoTracker Green FM for total mitochondria staining. NAC is a ROS inhibitor. (G) The oxLDL-induced mitochondrial membrane potential loss. (H) Tan IIA inhibition on oxLDL-induced mitochondrial membrane potential loss. ATP as a positive control for oxLDL-induced the loss of mitochondrial membrane potential.