Table 1. The top 20 hub genes in the PPI networks.

Overexpressed gene		Underexpressed gene
Gene symbol	Degree	Gene symbol	Degree
CDK1	113	ESR1	13
CCNB1	108	IGF1	10
CCNA2	105	PDGFRB	8
CDC20	104	PXN	7
TOP2A	103	ZEB1	6
CCNB2	102	MMP2	6
MAD2L1	99	IRS1	6
BUB1	96	BCL2	5
KIF11	94	PPID	4
RRM2	89	ITGA3	3
CDC45	89	RUNX1T1	3
EXO1	86	NEGR1	3
CHEK1	85	PDGFD	3
MELK	84	MEIS1	3
NDC80	84	PBX1	3
UBE2C	83	FRS2	2
TYMS	82	ALCAM	2
CENPA	82	TOX3	2
KIF23	80	WISP2	2
MCM2	80	RTN1	2