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COX-1 and COX-2 in Gastrointestinal Defense.
Prostaglandins (PGs) derived from the COX-1/COX-2 isoforms affect different aspects of mucosal defense. Cyclooxygenase-1 produces the PGs that regulate epithelial secretion of mucus and bicarbonate and mucosal blood flow, while COX-2 produces PGs that affect endothelial-leukocyte adherence and epithelial proliferation.
