Table 5.
N | No. of dementia | Crude OR | 95% C.I. | p-value | Adjusted OR† | 95% C.I. | p-value | |
---|---|---|---|---|---|---|---|---|
Female Allopurinol (days) |
||||||||
None | 1,016 | 505 | 1 | 1 | ||||
<90 | 125 | 65 | 1.09 | 0.75–1.60 | 0.644 | 1.02 | 0.66–1.56 | 0.935 |
90–179 | 41 | 24 | 1.41 | 0.76–2.64 | 0.280 | 1.32 | 0.67–2.61 | 0.423 |
≥180 | 120 | 57 | 0.93 | 0.63–1.35 | 0.690 | 0.89 | 0.57–1.40 | 0.623 |
Benzbromarone (days) | ||||||||
None | 348 | 181 | 1 | 1 | ||||
<90 | 425 | 219 | 1.01 | 0.77–1.32 | 0.957 | 0.99 | 0.73–1.36 | 0.964 |
90–179 | 166 | 89 | 1.09 | 0.75–1.59 | 0.640 | 0.90 | 0.58–1.39 | 0.643 |
≥180 | 363 | 162 | 0.74 | 0.55–0.99 | 0.045 | 0.72 | 0.51–1.02 | 0.065 |
Sulfinpyrazone (days) | ||||||||
None | 1,253 | 626 | 1 | 1 | ||||
<90 | 19 | 9 | 0.90 | 0.37–2.21 | 0.819 | 1.10 | 0.41–2.98 | 0.847 |
≥90 | 30 | 16 | 1.14 | 0.56–2.34 | 0.715 | 1.49 | 0.64–3.44 | 0.353 |
Probenecid | ||||||||
None | 1,289 | 644 | 1 | 1 | ||||
Yes | 13 | 7 | 1.17 | 0.39–3.47 | 0.782 | 1.34 | 0.40–4.48 | 0.631 |
Male Allopurinol (days) |
||||||||
None | 1,312 | 640 | 1 | 1 | ||||
<90 | 258 | 126 | 1.00 | 0.76–1.31 | 0.996 | 0.91 | 0.67–1.25 | 0.573 |
90–179 | 77 | 44 | 1.39 | 0.88–2.21 | 0.159 | 1.66 | 0.96–2.86 | 0.068 |
≥180 | 293 | 160 | 1.27 | 0.98–1.65 | 0.069 | 1.14 | 0.83–1.57 | 0.404 |
Benzbromarone (days) | ||||||||
None | 443 | 245 | 1 | 1 | ||||
<90 | 534 | 268 | 0.81 | 0.63–1.04 | 0.099 | 0.87 | 0.65–1.17 | 0.348 |
90–179 | 226 | 111 | 0.78 | 0.57–1.07 | 0.122 | 0.80 | 0.55–1.17 | 0.252 |
≥180 | 737 | 346 | 0.71 | 0.55–0.90 | 0.005 | 0.68 | 0.51–0.91 | 0.010 |
Sulfinpyrazone (days) | ||||||||
None | 1,853 | 923 | 1 | 1 | ||||
<90 | 38 | 21 | 1.24 | 0.65–2.34 | 0.517 | 1.56 | 0.74–3.31 | 0.246 |
≥90 | 49 | 26 | 1.14 | 0.64–2.05 | 0.655 | 1.36 | 0.70–2.64 | 0.364 |
Probenecid | ||||||||
None | 1,925 | 959 | 1 | 1 | ||||
Yes | 15 | 11 | 2.75 | 0.88–8.64 | 0.083 | 1.75 | 0.51–6.02 | 0.372 |
Adjusted for allopurinol, benzbromarone, sulfinpyrazone, probenecid, hypertension, hyperlipidemia, chronic liver disease, chronic kidney disease, diabetes, COPD, autoimmune disease, cardiovascular disease, stroke, depression, parkinson's disease, warfarin, and statin.