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. 2021 Jan 12;7:607808. doi: 10.3389/fmed.2020.607808

Table 5.

Conditional logistic regression of risk of dementia divided by anti-gout preparations use days in different sex.

N No. of dementia Crude OR 95% C.I. p-value Adjusted OR 95% C.I. p-value
Female
Allopurinol (days)
    None 1,016 505 1 1
     <90 125 65 1.09 0.75–1.60 0.644 1.02 0.66–1.56 0.935
    90–179 41 24 1.41 0.76–2.64 0.280 1.32 0.67–2.61 0.423
    ≥180 120 57 0.93 0.63–1.35 0.690 0.89 0.57–1.40 0.623
Benzbromarone (days)
    None 348 181 1 1
     <90 425 219 1.01 0.77–1.32 0.957 0.99 0.73–1.36 0.964
    90–179 166 89 1.09 0.75–1.59 0.640 0.90 0.58–1.39 0.643
    ≥180 363 162 0.74 0.55–0.99 0.045 0.72 0.51–1.02 0.065
Sulfinpyrazone (days)
    None 1,253 626 1 1
     <90 19 9 0.90 0.37–2.21 0.819 1.10 0.41–2.98 0.847
    ≥90 30 16 1.14 0.56–2.34 0.715 1.49 0.64–3.44 0.353
Probenecid
    None 1,289 644 1 1
    Yes 13 7 1.17 0.39–3.47 0.782 1.34 0.40–4.48 0.631
Male
Allopurinol (days)
    None 1,312 640 1 1
     <90 258 126 1.00 0.76–1.31 0.996 0.91 0.67–1.25 0.573
    90–179 77 44 1.39 0.88–2.21 0.159 1.66 0.96–2.86 0.068
    ≥180 293 160 1.27 0.98–1.65 0.069 1.14 0.83–1.57 0.404
Benzbromarone (days)
    None 443 245 1 1
     <90 534 268 0.81 0.63–1.04 0.099 0.87 0.65–1.17 0.348
    90–179 226 111 0.78 0.57–1.07 0.122 0.80 0.55–1.17 0.252
    ≥180 737 346 0.71 0.55–0.90 0.005 0.68 0.51–0.91 0.010
Sulfinpyrazone (days)
    None 1,853 923 1 1
     <90 38 21 1.24 0.65–2.34 0.517 1.56 0.74–3.31 0.246
    ≥90 49 26 1.14 0.64–2.05 0.655 1.36 0.70–2.64 0.364
Probenecid
    None 1,925 959 1 1
    Yes 15 11 2.75 0.88–8.64 0.083 1.75 0.51–6.02 0.372

Adjusted for allopurinol, benzbromarone, sulfinpyrazone, probenecid, hypertension, hyperlipidemia, chronic liver disease, chronic kidney disease, diabetes, COPD, autoimmune disease, cardiovascular disease, stroke, depression, parkinson's disease, warfarin, and statin.