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. 2021 Jan 12;7:613475. doi: 10.3389/fmed.2020.613475

Figure 2.

Figure 2

The relative ACE2 protein expression in intestinal mucosal biopsy specimens from patients with CD by Immunohistochemistry assays. The expression level was measured by percentage of positively stained cells. The sample sizes of each group are shown in Supplementary Table 1. (A) ACE2 expression before and after anti-TNFα treatment (matched comparison). (B) ACE2 expression among different disease activity groups defined by endoscopic and histological assessment. Median and interquartile range are shown in the scatterplot. (C) Spearman rank correlation analysis between ACE2 expression of colonic epithelial cells and endoscopic or histological disease activity. (D) Representative images (immunohistochemical staining for ACE2) of the colonic biopsy specimens before and after anti-TNFα treatment. (a–c) Biopsy before treatment. The histological score is 6. The percentage staining of ACE2 in colonic epithelial cells is 80%. (d–f) Biopsy after treatment. The histological score is 1. The percentage staining of ACE2 in colonic epithelial cells is 20%. All scale bars are 100 μm. ns, not significant; **P < 0.01; ***P < 0.001, ****P < 0.0001.