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. 2021 Jan 9;41(2):275–284. doi: 10.1007/s00296-020-04775-2

Table 1.

Meta-analysis estimates for prevalence of individual comorbidities

No. of studies No. of individuals Pooled prevalence 95% confidence interval I2, % Range
Any CVD 12 44,369 19.4 7.8–34.1 100 3.1–70.5
Any IHD 8 29,671 9.2 7.1–11.6 97 0.6–18.2
Angina 3 5828 3.6 1.4–6.6 94 1.9–5.1
Myocardial infarction 10 17,628 3.2 2.3–4.2 87 1.3–8.1
Heart failure 8 23,455 1.3 1.0–1.7 72 0.6–3.1
Stroke 15 42,872 2.8 1.5–4.5 98 0.0–21.8
PVD 8 44,629 1.6 0.5–3.3 99 0.0–6.2
Hypertension 31 85,014 34.2 28.6–40.2 100 6.4–62.7
Diabetes mellitus 32 89,972 12.9 10.7–15.2 99 2.0–34.1
Hyperlipidaemia 18 59,816 24.2 17.4–31.8 100 2.9–79.8
Obesity 15 27,890 27.4 24.5–30.4 95 12.7–39.8
Metabolic syndrome 5 1109 28.8 14.0–46.2 96 9.9–44.0
Any GI disease 5 11,976 9.9 7.9–12.0 71 6.0–16.0
Liver disease 10 73,289 3.4 0.1–9.6 100 0.0–26.5
Any pulmonary disease 6 68,370 12.3 6.3–19.8 100 5.0–22.7
COPD 6 12,517 3.4 0–10.4 99 1.1–17.3
Depression 14 91,541 11.9 7.4–17.2 100 0.8–27.2
Any cancer 11 63,670 5.2 4.2–6.4 96 1.5–9.2
Renal disease 8 33,051 2.5 0.8–4.9 99 1.0–8.1
Osteoporosis 4 18,215 9.3 3.0–18.3 99 3.8–14.0
Thyroid disorders 5 25,316 10.5 7.7–13.7 94 0.6–15.0

Stroke includes cerebrovascular accidents and transient ischaemic attacks. PVD peripheral vascular disease, COPD chronic obstructive pulmonary disease, GI gastrointestinal