Table 3.
Studies examining the effect of comorbidities on PsA disease outcomes
| Study | How comorbidity was examined | Outcome | Results |
|---|---|---|---|
| Aydin 2016 (abstract) [22] | Patient reported |
Tender joints Pain Patient global Assessment fatigue |
Patients with at least one comorbidity had a higher disease activity than none: Tender joint count (3.9 vs. 2.9, p = 0.001), Pain (4.6 vs. 4.0, p = 0.006), Patient global assessment (4.5 vs. 4.0, p = 0.014), Fatigue (4.9 vs. 4.0, p < 0.001) |
| Bavière 2020 [19] | Modified RDCI derived from patient and physician report | SF-36 Physical (PCS) and Mental component scores (MCS) |
In multivariable analysis of MCS, anxiety was strongly associated (β = − 10.81, p < 0.0001), however this was not seen for any other comorbidities MCS was significantly associated with the number of comorbidities (β = − 3.68, p < 0.0001) and mRDCI score (β = − 1.56, p = 0.0167) |
| Husted 2013 [20] | Self-report and medical records | SF-36 PCS and MCS |
Patients with ≥ 3 comorbidities had lower (i.e. poorer) PCS (42.2 vs. 46.4) and MCS (46.4 vs. 48.5) than those with < 3 comorbidities In multivariable models, only fibromyalgia and neurological disorders were significantly associated with PCS (p < 0.001) while only fibromyalgia and anxiety/depression were associated with MCS |
| Fernandez-Carballido 2020 [23] | Medical records, to calculate CCI | HAQ |
Patients with CCI > 1 had higher HAQ than CCI = 1 (median 0.75 vs. 0.25 p < 0.001) In multivariable analysis, HAQ was associated with: CCIp: β = 0.21 p < 0.001 Obesity: β = 0.19 p < 0.001 Hypertension: β = 0.20 p < 0.001 GI bleed: β = 0.49 p = 0.16 Hiatus hernia: β = 0.17 p = 0.07 Thyroid disease: β = 0.18 p = 0.06 |
| Stober 2018 [21] | Medical records | Discontinuation of the first TNF inhibitor | In multivariable models, metabolic syndrome-related comorbidities were independently significantly associated with TNFi discontinuation (HR 2.65; p = 0.01) |
PsA psoriatic arthritis, TNFI tumour necrosis factor inhibitor, HR hazard ratio, FM fibromyalgia, SF-36 Short Form-36, PCS Physical component score, MCS Mental component scores, CCIp Charlson Comorbidity Index proxy, mRDCI modified Rheumatic Disease Comorbidity Index (mRDCI), HAQ Health Assessment Questionnaire