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. 2021 Jan 25;11:2158. doi: 10.1038/s41598-020-79607-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vital status in wildtype, C5aR1 and C5aR2 knockout mice after sham or PT + HS. (A) MAP measurement at different time-points, (B) volume of blood drawn to induce HS in PT + HS animals, (C) blood hemoglobin and (D) total amount of catecholamine required to maintain blood pressure at 50 ± 5 mmHg. For (C), two-way ANOVA with Student-Newman-Keul’s post-hoc analysis was performed, with * and # denoting p < 0.05 for WT vs C5aR2 and C5aR1 KO vs C5aR2 KO PT + HS animals, respectively. (D) Catecholamine requirement to restore MAP ≥ 50 mmHg. Within the PT + HS groups, one-way ANOVA with Student-Newman-Keul’s post-hoc analysis was performed to compare between WT, C5aR1 KO and C5aR2 KO animals and * denotes p < 0.05.