Table 3.
Mutation frequency noncoding genes.
| Metastatic CRC | Primary CRC - (ICGC) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENSG | Symbol | Size | Chr | Type | Mutation rate | FDR Hochberg | Mutations (N) | Mutations (%) | Mutations (N) | Mutations (%) | Fisher p-value | FDR Hochberg |
| ENSG00000273001 | AL731533.2 | 577 | 10 | lncRNA | 0.067591 | 0 | 6 | 1.4 | 0 | 0 | 0.001291 | 3.87E-03 |
| ENSG00000280325 | AC074183.2 | 921 | 7 | TEC | 0.033659 | 0 | 25 | 5.8 | a | a | ||
| ENSG00000261584 | AL513548.1 | 1723 | 6 | lncRNA | 0.012768 | 9.93E-24 | 14 | 3.3 | 3 | 0.3 | 3.84E-05 | 2.09E-04 |
| ENSG00000259834 | AL365361.1 | 3480 | 1 | lncRNA | 0.007184 | 2.48E-09 | 17 | 4.0 | 0 | 0 | 5.62E-09 | 7.30E-08 |
| ENSG00000264920 | AC018521.5 | 4583 | 17 | lncRNA | 0.00851 | 1.02E-08 | 16 | 3.7 | 1 | 0.1 | 2.06E-07 | 1.85E-06 |
| ENSG00000231784 | DBIL5P | 2676 | 17 | Transcribed_unitary_pseudogene | 0.008595 | 6.26E-07 | 18 | 4.2 | 1 | 0.1 | 2.39E-08 | 2.63E-07 |
| ENSG00000273033 | LINC02035 | 5475 | 3 | lncRNA | 0.006758 | 9.54E-06 | 23 | 5.4 | 0 | 0.0 | 6.15E-12 | 8.61E-11 |
| ENSG00000266979 | LINC01180 | 3985 | 17 | lncRNA | 0.005521 | 1.18E-05 | 13 | 3.0 | 1 | 0.1 | 5.00E-06 | 4.00E-05 |
| ENSG00000272070 | AC005618.1 | 3147 | 5 | lncRNA | 0.006991 | 4.19E-05 | 18 | 4.2 | 1 | 0.1 | 2.39E-08 | 2.63E-07 |
| ENSG00000251562 | MALAT1 | 8828 | 11 | lncRNA | 0.005551 | 0.000283 | 30 | 7.0 | 19 | 2.2 | 4.19E-05 | 2.09E-04 |
| ENSG00000261094 | AC007066.2 | 2710 | 9 | lncRNA | 0.008118 | 0.000287 | 11 | 2.6 | 2 | 0.2 | 1.86E-04 | 7.43E-04 |
| ENSG00000263874 | LINC00672 | 4216 | 17 | Protein_coding | 0.005455 | 0.000493 | 14 | 3.3 | 2 | 0.2 | 9.70E-06 | 6.79E-05 |
| ENSG00000180764 | PIPSL | 3349 | 10 | Transcribed_processed_pseudogene | 0.006569 | 0.0013 | 14 | 3.3 | 34 | 3.9 | 0.640 | 0.640 |
| ENSG00000237984 | PTENP1 | 3995 | 9 | Transcribed_processed_pseudogene | 0.005507 | 0.0013 | 15 | 3.5 | 22 | 2.5 | 0.376 | 0.640 |
| ENSG00000240859 | AC093627.4 | 5916 | 7 | lncRNA | 0.006085 | 0.0048 | 18 | 4.2 | 2 | 0.2 | 1.66E-07 | 1.66E-06 |
Fifteen noncoding genes with an enriched mutation rate compared to surrounding nonannotated regions. P-values are derived from the Fisher exact test (two-sided) and corrected for multiple testing using the FDR (Hochberg) method.
aENSG not recognised by ICGC data portal.