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. 2021 Jan 25;6:15. doi: 10.1038/s41541-020-00277-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Neutralizing antibody responses as measured by TZM-bl cell-based assay at pre-immune, week 0 (a) and post-boost, week 32 (b) time points. TZM-bl cell-based neutralization assays were performed against both Tier 1 and Tier 2 viruses. Curve-based log ID50 values for pre-immunization and post-protein boost time points are shown for plasmid DNA (green circles), rMVA (red triangles), and rVSV (lavender diamonds), and protein only control (orange squares) groups. ID50 titers against seven different viruses, HIV-1 SF162, BG1168.1, 92RW020.5, TV.21, HIV-MN.3, MW965.26, and HIV-SS1196.01 are shown with geometric mean with 95% CI of the six monkeys per group. c Binding antibody titers elicited by different priming immunizations. ELISA binding titers (log AUC) of plasma against autologous (upper panels) and heterologous (lower panels) antigens from individual monkeys in four vaccine groups are shown at Week 2 (black symbols), Week 10 (green symbols), and post-boost (red symbols) time points. The lines indicate the median of the six monkeys per group.