Figure 3.

Specific recognition of inhibitors within FTO. (A) Meclofenamic acid (MA) binds to the deep pocket on the surface of FTO (PDB ID: 4QKN) (represented by gray semitransparent surface); MA represented by yellow residue binds to both H₂O yellow circle and S229 yellow residue by blue covalent bonds. (B) Rhein RHN binds to the deep pocket on the surface of FTO (PDB ID: 4IE7) (represented by gray semitransparent surface); RHN is represented by yellow residue binds to the active site residues by blue covalent bonds. (C) Detailed view of meclofenamic acid (MA) within FTO (PDB ID: 4QKN) active residues (gray carbon residues identified by their numbers); MA is represented by yellow color residue, attached to the active site residues by blue covalent bonds; 2-oxoglutarate analog (NOG) is represented by red carbon residues; nickel (Ni) atom is represented by a pink circle. H₂O is represented by a pink circle. (D) Detailed view of Rhein (RHN) within FTO (PDB ID: 4IE7) active residues (gray carbon residues identified by their numbers); RHN is represented by yellow color residue, attached by active site residues by blue covalent bonds; citrate molecule (CIT) is represented by red residue; zinc (Zn) atom is represented by a dark gray circle.