Table 1.

Regulatory aspects of m⁶A demethylases.

m6A demethylase	Regulatory aspect	Tissue involved	Regulatory Gene(s) & their expression level	References
ALKBH5	Cancer type	Breast cancer	↑NANOG	Zhang et al., 2016a,b
		Glioblastoma	↑FOXM1	Dixit et al., 2017; Zhang et al., 2017; Malacrida et al., 2020
		Lung adenocarcinoma	↑FOXM1	Chao et al., 2020
		Pancreatic cancer	↑KCNK15-AS1 ↑WIF- 1	He et al., 2018 Tang et al., 2020
		Bladder cancer	↓ITGA6	Jin et al., 2019
		Oral squamous cell carcinoma	↑FOXM1 / NANOG	Shriwas et al., 2020
		Osteosarcoma	↑PVT1	Int et al., 2020
		Gastric cancer	↑NEAT1	Zhang J. et al., 2019; Zhu et al., 2020
		Colon cancer		Yang P. et al., 2019
		Ovarian cancer	↑Bcl2	Zhu et al., 2019
		Male germ cell tumor		Nettersheim et al., 2019
	Metabolic disorder	Male infertility	↑Correct spliced/longer transcripts	Tang et al., 2017
		Autophagy (ischemic heart disease)	↑TFEB	Song et al., 2019
	Differentiation	Placenta	↓CYR61	Li et al., 2019
		Adipogenesis	↓CEBPb	Choi et al., 2019
		Myogenesis	↓Myogenin	Choi et al., 2019
FTO	Cancer type	Breast cancer	↓BNIP3	Niu et al., 2019
		Melanoma	↑PD-1 CXCR4 SOX10	Yang S. et al., 2019; Melstrom and Chen, 2020; Zhao et al., 2020
		Acute myeloid leukemia	↓ASB2 and RARA	Li Z. et al., 2017; Huang et al., 2019; Weng et al., 2019; Zhao et al., 2020
		Gastric cancer		Xu et al., 2017; Zhang C. et al., 2019
	Metabolic disorder	Obesity	FTO gene Intron1 IRX3	Zhao et al., 2014b Smemo et al., 2014
		Premature ovarian insufficiency		Ding et al., 2018
	Differentiation	Neuronal stem cells		Cao et al., 2019