Table 3.

Diagnostic performances of single and combined markers

Variables	AUC	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Efficiency (%)
Healthy vs CRC
CEA ng/ml	0.37	2.8	79	10	68	17	59
CA 19.9 μ/ml	0.41	23.4	77	10	67	15	57
PLR	0.73	4.9	47	65	76	34	52
SCF ng/ml	0.80	539	58	90	93	47%	63
LRG1 μg/ml	0.87	60	52	90	93	44	68
SCF-LRG1	0.9	3.6	85	80	91	70	84
CRC vs Benign
CEA ng/ml	0.44	2.8	79	20	70	29	62
CA 19.9 μ/ml	0.50	23.4	77	30	73	35	63
PLR	0.48	4.9	45	60	72	32	49
SCF ng/ml	0.72	539	58	70	82	41	61
LRG1 μg/ml	0.84	60	54	95	96	46	66
SCF-LRG1	0.84	3.6	79	70	86	58	77
Treated CRC vs non-treated CRC
CEA ng/ml	0.59	2.8	82	23	47	60	50
CA 19.9 μ/ml	0.64	23.4	82	27	49	64	52
PLR	0.76	4.55	71	69	65	75	70
SCF ng/ml	0.68	539	73	54	57	70	63
LRG1 μg/ml	0.82	61.5	82	73	72	83	73
SCF-LRG1	0.84	3.6	77	70	68	78	77