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. 2021 Jan 25;7:23. doi: 10.1038/s41420-020-00383-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Heatmap depicting the expression of upregulated (32) and downregulated (129) genes (1.5 ≤ fc ≥ 1.5) in the BT-549 and MDA-MB-231 TNBC models using whole transcriptome analysis. b Principal component analysis (PCA) illustrating the segregation of BT-549, BT-549-MALAT1-KO, MDA-MB-231, and MDA-MB-231-MALAT1-KO based on PC1 and PC2. Ingenuity pathway analysis (IPA) on the 161 common differentially expressed transcripts in MALAT1-KO TNBC models highlighting suppression of INFG, NFKB, and TNF networks (c). Suppression of NUPR1, STAT1, RELA, and SREBF1 transcription regulator (d), angiogenesis functional category (e), as well as oxidative phosphorylation canonical pathway (f) in MALAT1-KO TNBC cells.