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. 2021 Jan 25;12:582. doi: 10.1038/s41467-020-20828-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic representation of TNFR1 dimers (pink and purple) pre-clustered, with a portion bound to TNF (green) (two copies of TNFR1 dimer bound per TNF trimer). Addition of more TNF (green) results in linking of the TNF-two-receptor-bound units into larger TNF-three-receptor-bound clusters finally assembling into a large network. b Same scenario as a in the presence of compound (yellow dots), resulting in incomplete network assembly.