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. 2020 Nov 20;8(1):309–316. doi: 10.1002/ehf2.13063

Figure 2.

Figure 2

Sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) expression in the blood of COVID‐19 patients. (A) NHE1 expression is significantly increased in whole blood of patients with SARS‐CoV‐2 infection (SARS‐CoV‐2 positive) at first contact in the emergency department compared with control (CTRL; P = 0.01, Mann–Whitney U test). (B) GLUT1 expression is not significantly altered in whole blood of patients with SARS‐CoV‐2 infection compared with CTRL (P = 0.29, Mann–Whitney U test). (C) The ratio of GLUT1 and NHE1 is significantly decreased in patients with SARS‐CoV‐2 infection compared with CTRL (P = 0.0039, Mann–Whitney U test). (D and E) In patients with COVID‐19 at first contact in the emergency department, (D) NHE1 or (E) GLUT1 expression is not significantly different in patients who later develop moderate disease (MD) compared with patients later requiring intubation and/or dying [severe disease (SD); (D): P = 0.99, t‐test; (E): P = 0.30, t‐test]. (F) GLUT1 to NHE1 ratio is significantly decreased in patients with SD compared with patients with MD (P = 0.036, Welsh t‐test).