Figure 8.
Therapeutic effect of NBP during tMCAO. Diagram illustrates that adult SD rats underwent tMCAO and were treated with NBP for 3 days. The results demonstrated that NBP treatment could increase CBF of the ipsilateral hemisphere, attenuate infarct volume and brain edema, reduce BBB disruption, and inhibit ischemia-induced increase in AQP4 and MMP-9 expression, which is associated with MAP kinase phosphorylation.