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. 2021 Jan 12;8:620667. doi: 10.3389/fcell.2020.620667

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Copyright © 2021 Jones, Chong and Bellusci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of ECM remodeling and tissue fluidity. Mesenchymal tissue fluidity increases around distal bud tips in response to increased MMP activity. Increased fluidity increases expression of tenascin-C (TNC) around distal tips. TNC regulates mesenchymal Fgf10 activity, and is perhaps itself regulated by Fgf10. Hoxb-5 regulates TNC expression, and also the domain of Fgf10 expression, either directly, or indirectly via TNC regulation. Increased ECM fluidity corresponds to basement membrane thinning (e.g., lower Lama1 expression), which results in increased ROCK signaling-directed cellular rearrangements. Mesen., Mesenchyme; BM, Basement membrane; Epith., Epithelium. Dark and light blue ovals represent localized sources of high and low Fgf10 expression, respectively.