TABLE 2.

Summary of lesions in adrenal glands induced by SARS-CoV-2 at 7 dpi.

Degree	H&E	ISH	IHC	Notes
Normal (3/18)	No substantial pathological change (3/18)	No detectable viral RNA (3/18)	No detectable viral S protein (3/18)	The ratings of the three hamsters were the same.
Mild (2/18) to moderate (7/18)	Focal (2/18) to multifocal (7/18) inflammation	Low viral RNA expression in the adrenal medulla (7/18)	Weak viral S protein expression in the adrenal medulla (7/18)	In 2/18 hamsters, there was focal inflammation without detectable viral RNA or antigen.
Severe (6/18)	Diffuse inflammation (6/18)	Robust viral RNA expression in the adrenal cortex and medulla (6/18)	Viral S protein detected mainly in the adrenal medulla (6/18)	The ratings of the three hamsters were the same.