Table 1.
Ongoing clinical trials of IGF-1R inhibitors in cancers.
| Drug | Combination therapy | Indicated diseases | Phase | NCT number | Status# |
|---|---|---|---|---|---|
| Ganitumab (AMG479) |
- | Metastatic or recurrent sarcoma | 1 | NCT04199026 | NR |
| Combination chemotherapy | Newly diagnosed metastatic Ewing sarcoma | 3 | NCT02306161 | Ac/NR | |
| Dasatinib | Rhabdomyosarcoma | 1/2 | NCT03041701 | R | |
| Metformin | Breast cancer | 2 | NCT01042379 | R | |
| Palbociclib | Ewing sarcoma | 2 | NCT04129151 | R | |
| Cixutumumab (IMC-A12) |
Paclitaxel | Metastatic esophageal cancer or gastroesophageal junction cancer | 2 | NCT01142388 | Ac/NR |
#
R, recruiting; Ac/NR, active not recruiting; NR, not yet recruiting.