TABLE 3.

Overview of the affected physiological mechanisms in POR and AMA patients following KEGG analysis.

Affected pathways	POR	AMA
Signaling pathways and signal transduction
PI3K-Akt signaling pathway	†	†
mTOR signaling pathway	†	†
TGF-β signaling pathway	†
FoxO signaling pathway	†
Wnt signaling pathway	†
Hippo signaling pathway	†
Ras signaling pathway	†	†
EGFR tyrosine kinase inhibitor resistance pathway	†	†
AMPK signaling pathway	†	†
MAPK pathway	†	†
p53 signaling pathway	†	†
N eurotrophins signaling pathway	†	†
ErbB(/EGFR) signaling pathway	†	†
JAK-STAT signaling pathway	†	†
Cellular functions and interactions
Regulation of actin cytoskeleton	†	†
Oocyte meiosis	†
Apoptosis	†
Cellular senescence	†	†
Mitophagy		†
Gap junctions	†
Hormonal signaling
Growth hormone synthesis, secretion and action	†	†
Protein Regulation
N-glycan biosynthesis	†	†
Glucose Metabolism	†	†

^† This symbol indicates the category of patients a certain pathway is disregulated in.