Table 4.

Sensitivity to change: mean 1 month change in TASQ stratified by change in NYHA class

Domain vs. NYHA	Total (N = 243)	↓ by 3 (N = 3)	↓ by 2 (N = 39)	↓ by 1 (N = 106)	No change (N = 77)	Worsening (N = 11)	P‐value for trend a
Physical symptoms (1, 14)	2.00	3.33	2.49	2.71	0.89	−0.00	<0.001
Physical limitations (3, 6, 7, 15)	5.55	7.33	7.01	7.00	3.10	1.09	<0.001
Emotional impact (2, 8–13)	4.83	9.67	8.18	5.79	2.27	−1.73	0.003
Social limitations (4, 5)	0.91	0.33	2.00	1.23	−0.07	−0.82	0.038
Health expectations (16)	−0.52	0.0	−0.21	−0.67	−0.35	−1.18	0.374
TASQ total score	13.06	20.67	19.42	16.31	6.24	−2.64	<0.001

NYHA, New York Heart Association; TASQ, Toronto Aortic Stenosis Quality of Life Questionnaire.

To examine the sensitivity of the TASQ to clinically relevant changes and its ability to discriminate between different levels of change, we calculated the change in domain scores for all patients from baseline to 1 month stratified by their change in NYHA class during the same period and examined the relation between the change in domain scores vs. the change in NYHA class using a linear trend test.

^aANOVA.