TABLE 6.
Significantly deregulated microRNAs in serum samples of dilated cardiomyopathy patients detected by the OpenArray® screening compared with healthy donors (left side) and patients with inflammatory and/or virally induced cardiomyopathies (right side)
MiRNA | Fold change | P‐value (−log 10) | MiRNA | Fold change | P‐value (−log 10) |
---|---|---|---|---|---|
hsa‐miR‐101 | 3.22 | 1.81 | hsa‐let‐7f | 0.33 | 2.28 |
hsa‐miR‐106b | 2.31 | 2.73 | hsa‐miR‐195 | 0.41 | 2.94 |
HSA‐MIR‐1180 | 3.38 | 1.34 | hsa‐miR‐21 | 1.10 | 1.95 |
hsa‐miR‐125b | 0.57 | 1.47 | hsa‐miR‐30a‐5p | 0.67 | 1.83 |
hsa‐miR‐130a | 2.26 | 1.47 | hsa‐miR‐422a | 0.37 | 1.71 |
hsa‐miR‐130b | 1.87 | 1.47 | hsa‐miR‐590‐5p | 0.43 | 2.48 |
hsa‐miR‐132 | 1.66 | 1.65 | |||
hsa‐miR‐140‐3p | 3.26 | 1.98 | |||
hsa‐miR‐141 | 2.75 | 2.60 | |||
hsa‐miR‐146b‐3p | 4.25 | 1.70 | |||
hsa‐miR‐155 | 2.69 | 1.54 | |||
hsa‐miR‐185 | 1.98 | 1.62 | |||
hsa‐miR‐18a | 1.97 | 2.81 | |||
hsa‐miR‐21 | 1.38 | 1.76 | |||
hsa‐miR‐223 | 0.29 | 2.51 | |||
hsa‐miR‐23a | 2.25 | 1.71 | |||
hsa‐miR‐296 | 2.10 | 1.84 | |||
hsa‐miR‐30a‐5p | 1.66 | 1.41 | |||
hsa‐miR‐30d | 2.04 | 2.06 | |||
hsa‐miR‐320 | 4.13 | 5.62 | |||
HSA‐MIR‐320B | 7.64 | 4.01 | |||
hsa‐miR‐323‐3p | 5.69 | 1.70 | |||
hsa‐miR‐335 | 2.14 | 1.41 | |||
hsa‐miR‐363 | 2.31 | 1.45 | |||
hsa‐miR‐365 | 0.47 | 1.91 | |||
hsa‐miR‐455 | 4.02 | 1.49 | |||
hsa‐miR‐486‐3p | 10.16 | 1.86 | |||
hsa‐miR‐502 | 3.42 | 4.30 | |||
hsa‐miR‐502‐3p | 3.42 | 1.35 | |||
hsa‐miR‐574‐3p | 0.63 | 2.14 | |||
hsa‐miR‐579 | 2.92 | 2.16 | |||
hsa‐miR‐624 | 2.28 | 1.97 | |||
hsa‐miR‐885‐5p | 0.35 | 2.08 | |||
hsa‐miR‐92a | 2.07 | 1.77 | |||
hsa‐miR‐942 | 1.68 | 1.43 | |||
hsa‐miR‐99a | 0.44 | 1.52 | |||
mmu‐miR‐134 | 2.63 | 1.45 | |||
mmu‐miR‐140 | 0.55 | 1.35 |
Only two microRNAs (miRNAs) (hsa‐miR‐21 and hsa‐miR‐30a‐5p) have been significantly different in dilated cardiomyopathy patients compared with healthy or inflammatory and/or virally induced subjects.