Table 4.
Relationship of the individual components and ischemic brain lesions.
| Clinically overt ischemic brain lesions (n = 183) | Silent ischemic brain lesions (n = 399) | Any ischemic brain lesion (n = 641) | |||||
|---|---|---|---|---|---|---|---|
| No. of Cases | Odds ratio (95% CI) | No. of Cases | Odds ratio (95% CI) | No. of Cases | Odds ratio (95% CI) | ||
| Components | Model 1* | Model 1* | Model 1* | Model 2† | |||
| History of heart failure | 46 | 0.96 (0.66, 1.39) | 109 | 1.31 (0.99, 1.71) | 168 | 1.19 (0.93, 1.53) | 1.24 (0.96, 1.61) |
| History of hypertension | 150 | 1.90 (1.28, 2.88) | 279 | 0.87 (0.67, 1.12) | 473 | 1.15 (0.92, 1.45) | 1.11 (0.87, 1.42) |
| Age | |||||||
| 65–74 years‡ | 72 | 2.58 (1.29, 5.90) | 161 | 1.95 (1.26, 3.10) | 256 | 2.51 (1.72, 3.77) | 2.16 (1.46, 3.29) |
| ≥75 years§ | 103 | 4.13 (2.07, 9.43) | 212 | 3.06 (1.98, 4.89) | 350 | 4.71 (3.20, 7.10) | 3.99 (2.67, 6.09) |
| History of diabetes | 42 | 1.48 (1.00, 2.18) | 69 | 0.98 (0.71, 1.34) | 120 | 1.16 (0.87, 1.53) | 1.09 (0.81, 1.46) |
| History of vascular disease | 61 | 0.90 (0.63, 1.28) | 153 | 1.39 (1.07, 1.79) | 237 | 1.31 (1.04, 1.64) | 1.30 (1.02, 1.65) |
| Female sex | 52 | 0.99 (0.69, 1.41) | 96 | 0.79 (0.60, 1.04) | 165 | 0.84 (0.66, 1.06) | 0.77 (0.60, 0.99) |
| History of stroke/TIA|| | 242 | 5.30 (4.08, 6.93) | |||||
CI, confidence interval; TIA, transient ischemic attack.
Model 1: The model was combined including all components of the CHA2D-VASc score (history of heart failure, history of hypertension, age 65–74 years and ≥75 years, history of diabetes, vascular disease and female sex).
Model 2: The model was combined including all components of the CHA2DS2-VASc score (history of heart failure, history of hypertension, age 65–74 years and ≥75 years, history of diabetes, vascular disease and female sex and history of stroke/TIA).
Clinically overt ischemic brain lesions were defined as ischemic brain lesions in patients with a history of stroke.
Silent ischemic brain lesions were defined as ischemic brain lesions in patients without a history of stroke/TIA.
Any ischemic brain lesion was defined as a composite of clinically overt and silent ischemic brain lesions including ischemic lesions in patients with history of TIA.
n = 789,
n = 722,
n = 348.