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. 2021 Jan 19;22(2):969. doi: 10.3390/ijms22020969

Figure 1.

Figure 1

Human cardiac SPAAR (small regulatory polypeptide of amino acid response) expression and LINC00961 response to hypoxia. Uniform manifold approximation and projection for dimension reduction (UMAP) visualisation of (A) human cardiac endothelial cells (EC, green), fibroblast (FB, red), pericyte (PC, grey), SMC (olive), cardiomyocyte (CMC, orange), adipocyte (blue), neuronal cell (pink), myeloid (brown), and lymphoid (purple) fraction [19], and (B) SPAAR expression in human cardiac cell populations. LINC00961 expression is reduced in bEnd.3 mouse cells following 24 h (C, black n = 3) and 48 h (D, black n = 3) exposure to hypoxia (H, 1% O2) compared with bEnd.3 cells cultured in normoxia (Nx, 5% O2) collected in parallel (both n = 3). Student’s t-test. Data are mean ± SEM. * p < 0.05, ** p < 0.01.