Table 1.

Adult post-mortem organ weights.

	Female		Male		Significance (p)
	WT n = 9	KO n = 9	WT n = 10	KO n = 9	Sex	Genotype	Interaction
Weight (g)	20.8 ± 0.9	20.9 ± 0.5	27.1 ± 0.6	23.7 ± 0.9	0.01	0.03	0.02
Brain (mg)	443.9 ± 8.8	428.4 ± 10.6	450.7 ± 5.3	435.5 ± 12.5	ns	ns	ns
Brain:Body weight (mg/g)	21.5 ± 0.5	20.5 ± 0.5	16.7 ± 0.4	18.5 ± 0.5	0.01	ns	0.009
Heart (mg)	124.2 ± 7.2	125.7 ± 9.6	137.0 ± 6.3	115.2 ± 6.6	ns	ns	ns
Heart:Body weight (mg/g)	6.0 ± 0.4	6.1 ± 0.4	5.0 ± 0.3	4.9 ± 0.3	0.03	ns	ns
Lungs, total (mg)	167.7 ± 16.5	147.1 ± 7.4	148.0 ± 3.6	139.9 ± 4.9	ns	ns	ns
Lungs:Body weight (mg/g)	7.5 ± 0.3	7.1 ± 0.3	5.5 ± 0.2	5.9 ± 0.3	0.01	ns	ns
Liver (mg)	1212 ± 64	1104 ± 34	1111 ± 71	1174 ± 69	ns	0.004	ns
Liver:Body weight (mg/g)	58.4 ± 2.5	53.2 ± 2.5	53.5 ± 2.4	49.6 ± 2.5	ns	ns	ns
Spleen, total (mg)	88.3 ± 5.8	88.0 ± 3.8	84.9 ± 4.3	80.3 ± 8.6	ns	ns	ns
Spleen:Body weight (mg/g)	4.2 ± 0.2	4.2 ± 0.2	3.1 ± 0.2	3.4 ± 0.2	0.009	ns	ns
Soleus, total (mg)	6.4 ± 0.4	6.4 ± 0.6	8.6 ± 0.6	8.1 ± 0.8	ns	ns	ns
Soleus:Body weight (mg/g)	0.31 ± 0.02	0.31 ± 0.03	0.32 ± 0.02	0.34 ± 0.03	ns	ns	ns
	WT n = 5	KO n = 8	WT n = 10	KO n = 8	Sex	Genotype	Interaction
Nose to anus (mm)	79.5 ± 1.5	79.7 ± 1.1	82.3 ± 1.1	79.0 ± 0.8	ns	ns	ns
Head length (mm)	25.0 ± 0.6	26.7 ± 0.3	26.4 ± 0.2	26.5 ± 0.6	ns	0.006	ns
Biparietal diameter (mm)	11.6 ± 0.2	11.2 ± 0.2	11.8 ± 0.1	11.7 ± 0.2	ns	ns	ns
Tibia length (mm)	15.4 ± 1.1	18.4 ± 0.7	17.5 ± 0.5	17.0 ± 0.4	ns	0.05	ns

Post-mortem organ weights were collected in female (WT, n = 5–9; KO, n = 8–9), and male (WT, n = 10; KO, n = 8–9) adults (9.7 ± 0.3 and 9.9 ± 0.3 weeks, respectively). Data are mean ± SEM. Statistical differences are indicated: main effect of sex, main effect of genotype, and sex × genotype interaction (two-way ANOVA with Tukey’s post-hoc comparison).