Figure 1.

Surgical treatment with gentamicin-loaded calcium sulphate-hydroxyapatite (CaS-HA) biocomposite of a diabetic foot ulcer, complicated by osteomyelitis, at the medial aspect of the first metatarsophalangeal joint. (A) After surgical excision of the foot ulcer, macroscopic necrotic bone and necrotic and infected soft tissues are resected. (B) The dead space is irrigated with saline solution, and gentamicin-loaded CaS-HA biocomposite is injected. (C) The dead space is filled with gentamicin-loaded CaS-HA biocomposite. (D) In this dorsal-plantar x-ray image of the foot, the gentamicin-loaded CaS-HA biocomposite is visible as a density in the distal part of the metatarsal and the proximal phalanx (encircled).