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. 2021 Jan 19;10(2):371. doi: 10.3390/jcm10020371

Table A1.

Surgical procedures with gentamicin-loaded calcium sulphate-hydroxyapatite biocomposite performed to treat diabetic foot ulcers complicated by osteomyelitis in this study.

Surgical Procedures No. (%)
Osteotomy of phalanx/phalanges, debridement and dead space filling with gentamicin-loaded CaS-HA biocomposite. 3 (5)
Arthrotomy of interphalangeal joint(s), resection with base and head of adjacent phalanges, dead space filling with gentamicin-loaded CaS-HA biocomposite. 3 (5)
Arthrotomy of interphalangeal joint(s), resection with base and head of adjacent phalanges, dead space filling with gentamicin-loaded CaS-HA biocomposite, arthrodesis with Kirschner wire. 3 (5)
Arthrotomy of metatarsophalangeal joint(s), resection with metatarsal head(s) and base of proximal phalanx/phalanges, dead space filling with gentamicin-loaded CaS-HA biocomposite. 14 (22)
Arthrotomy of metatarsophalangeal joint(s), resection with metatarsal head(s) and base of proximal phalanx/phalanges, dead space filling with gentamicin-loaded CaS-HA biocomposite, arthrodesis with Kirschner wire. 2 (3)
Osteotomy of metatarsal(s), debridement of medullary canal(s), filling with gentamicin-loaded CaS-HA biocomposite. 10 (16)
Amputation of metatarsal head(s), debridement of medullary canal(s) and filling with gentamicin-loaded CaS-HA biocomposite. 8 (13)
Arthrotomy of tarsometatarsal joint(s), resection of joint with distal part of one or multiple tarsals and base of one or multiple metatarsals, dead space filling with gentamicin-loaded CaS-HA biocomposite. 8 (13)
Arthrotomy of tarsometatarsal joint(s), resection with distal part of tarsal(s) and base of metatarsal(s), dead space filling with gentamicin-loaded CaS-HA biocomposite, temporary external fixation. 1 (2)
Arthrotomy of tarsometatarsal joint(s), resection with distal part of tarsal(s) and base of metatarsal(s), dead space filling with gentamicin-loaded CaS-HA biocomposite, internal screw fixation. 1 (2)
Partial or complete extirpation of tarsal(s), dead space filling with gentamicin-loaded CaS-HA biocomposite. 1 (2)
Partial or complete extirpation of tarsal(s), dead space filling with gentamicin-loaded CaS-HA biocomposite, temporary external fixation 2 (3)
Partial or complete extirpation of tarsal(s), dead space filling with gentamicin-loaded CaS-HA biocomposite, internal screw fixation. 1 (2)
Partial calcanectomy, surgical debridement and dead space filling with gentamicin-loaded CaS-HA biocomposite. 4 (6)
Partial calcanectomy, drilling of multiple tunnels in the calcaneum, filling with gentamicin-loaded CaS-HA biocomposite (“silo technique”) [24]. 3 (5)
Treatment Characteristics No. (%)
Volume of gentamicin-loaded CaS-HA biocomposite used (mL). 5 (4-5)
Form of gentamicin-loaded CaS-HA biocomposite used
  • -

    Fluid phase

 59 (92)
  • -

    Solid phase (e.g., pellets)

 5 (8)
Use of pressure tourniquet during surgical procedure. 21 (33)
Method of surgical wound closure
  • -

    Primary closure

 57 (89)
  • -

    Local transposition

 6 (9)
  • -

    Regional tissue transposition

 1 (2)
Perioperative antibiotic therapy
  • -

    None

 32 (50)
  • -

    Carbapenems

 1 (3)
  • -

    Cephalosporins

 7 (23)
  • -

    Cephalosporins + trimethoprim/sulfamethoxazole

 1 (3)
  • -

    Cephalosporins + fluoroquinolones

 1 (3)
  • -

    Cephalosporins + macrolides

 2 (6)
  • -

    Cephalosporins + metronidazole

 1 (3)
  • -

    Fluoroquinolones + macrolides

 5 (16)
  • -

    Penicillins

 11 (34)
  • -

    Penicillins + fluoroquinolones

 1 (3)
  • -

    Trimethoprim/sulfamethoxazole41

 1 (3)
  • -

    Vancomycin

 1 (3)
Route of administration of perioperative antibiotic therapy
  • -

    Oral

 6 (9)
  • -

    Parenteral

 26 (41)
Method of anaesthesia
  • -

    General

 18 (28)
  • -

    Spinal

 15 (24)
  • -

    Regional

 29 (45)
  • -

    Local

 2 (3)
Duration of surgery (minutes) 46 ± 21

Data are presented as number (%), mean ± SD or median (IQR). CaS-HA: Calcium sulphate-hydroxyapatite.