Figure 1.

The peroxidase system of the natural saliva defense system generates hydrogen peroxide by the enzyme glucose oxidase and initiates the oxidation of thiocyanate (SCN−) to hypothiocyanite (HOSCN/OSCN−) by the enzyme lactoperoxidase (LPO). The enzyme-containing toothpastes abstain from starch and amyloglucosidase for D-glucose delivery. D-Glucose was directly formulated in the toothpastes together with glucose oxidase. Thiocyanate and LPO are only added to the prototype 755 (see Table 2). The prototypes 255, 258, and C58 rely on the endogenous salivary LPO and thiocyanate for the production of hypothiocyanite.