TABLE 4.
Knowledge of pharmacogenetics among healthcare professionals about antimicrobial resistance, Lusaka Zambia 2019.
| Pharmacogenetics questions | Total (n = 304) | Nurses (n = 100) | Physicians (n = 65) | Pharmacists (n = 58) | Biomedical personnel (n = 80) | p-value |
|---|---|---|---|---|---|---|
| 1. Are you aware of individual variation in the way antibiotics work and in the way different individuals experience adverse drug reactions and/or toxicity to antibiotics? | 240 (81.1) | 67 (69.1) | 59 (92.2) | 49 (85.9) | 65 (83.3) | 0.001 |
| 2. Have you heard of the term pharmacogenetics and know what it means? | 225 (76.0) | 54 (55.7) | 52 (82.5) | 53 (91.4) | 66 (84.6) | <0.001 |
| 3. Is genetic testing important in the use of medicines for reducing cost of treatment? | 100 (33.4) | 34 (35.1) | 12 (18.8) | 25 (43.1) | 29 (36.3) | 0.029 |
| 4. Is genetic testing important in the use of medicines for understanding drug action? | 102 (34.1) | 32 (32.9) | 17 (26.6) | 23 (39.7) | 30 (37.5) | 0.411 |
| 5. Is genetic testing important in the use of medicines for reducing adverse drug reactions? | 125 (42.1) | 25 (26.0) | 27 (42.2) | 37 (63.8) | 36 (45.6) | <0.001 |
| 6. Is genetic testing important in the use of medicines for improving efficacy? | 104 (35.0) | 24 (25.0) | 14 (21.9) | 31 (53.5) | 35 (44.5) | <0.001 |
| 7. Is the knowledge of genetic testing in drug use likely to decrease the number of adverse drug reactions? | 88 (29.8) | 18 (18.9) | 12 (18.8) | 28 (49.1) | 30 (37.9) | <0.001 |
| 8. Is the knowledge of patient genetic make-up likely to decrease the cost of developing drugs? | 15 (15.6) | 8 (12.5) | 14 (24.1) | 28 (49.1) | 20 (25.3) | 0.141 |
| Overall score (mean ± SD)a | 3.04 ± 1.1 | 2.5 ± 0.8 | 2.7 ± 0.9 | 3.8 ± 1.1 | 3.4 ± 1.2 | <0.001 |
aAll values are mean and Standard Deviation (SD) and p-value from One Way Analysis of Variance (ANOVA). Otherwise, Chi-square tests were used.