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Cartoon illustrating the potential cascade of events due to the physical interaction of E7wt with GSN. In this model, we suggest a crucial role of the molecular association of E7wt with GSN in HPV-positive tumor cell motility and aggressiveness. In this process, the activation of Rac1 and Cdc42 and the increase of polymerization state of actin would be decisive in inducing EMT-related morpho-functional alterations via YAP signaling.
