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. 2021 Jan 11;11:613780. doi: 10.3389/fphar.2020.613780

TABLE 2.

Pieces of evidence that support the theory of oxidative modification.

Pieces of evidence that support the theory of oxidative modification References
LDL oxidation was observed in vivo Palinski et al. (1989)
OxLDL was found in atherosclerotic lesions Nishi et al. (2002)
Autoantibodies are generated against oxLDL Wu and Lefvert (1995)
Titers of autoantibodies correlate with the extent of atherosclerosis Bergmark et al. (1995)
Knocking out scavenger receptors (both scavenger receptor A or CD36) ameliorates atherosclerosis Moore and Freeman (2006)
Knocking out 12/15-lipoxygenase that can oxidize LDL ameliorates atherosclerosis Cyrus et al. (1999)