TABLE 2.

Pieces of evidence that support the theory of oxidative modification.

Pieces of evidence that support the theory of oxidative modification	References
LDL oxidation was observed in vivo	Palinski et al. (1989)
OxLDL was found in atherosclerotic lesions	Nishi et al. (2002)
Autoantibodies are generated against oxLDL	Wu and Lefvert (1995)
Titers of autoantibodies correlate with the extent of atherosclerosis	Bergmark et al. (1995)
Knocking out scavenger receptors (both scavenger receptor A or CD36) ameliorates atherosclerosis	Moore and Freeman (2006)
Knocking out 12/15-lipoxygenase that can oxidize LDL ameliorates atherosclerosis	Cyrus et al. (1999)