. 2020 Dec 8;78(4):1473–1492. doi: 10.3233/JAD-200615

Table 5.

Group-wise comparisons of hippocampal and cortical volumes in the participants with amnestic mild cognitive impairment

(I) Groupcode	(J) Groupcode	Mean difference (I-J)	p	95% Confidence interval for difference
				Lower bound	Upper bound
Left hippocampal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.376	0.655	–1.099	0.346
	ɛ4^–/BDNF^Met	–1.394	0.001	–2.345	–0.443
	ɛ4^–/BDNF^Val/Val	–0.967	0.019	–1.823	–0.111
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–1.018	0.006	–1.825	–0.211
	ɛ4^–/BDNF^Val/Val	–0.590	0.123	–1.270	0.090
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.428	0.767	–0.500	1.355
Right hippocampal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.093	1.000	–0.926	0.739
	ɛ4^–/BDNF^Met	–1.136	0.038	–2.232	–0.041
	ɛ4^–/BDNF^Val/Val	–0.348	0.919	–1.334	0.638
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–1.043	0.020	–1.973	–0.113
	ɛ4^–/BDNF^Val/Val	–0.255	0.944	–1.038	0.528
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.788	0.263	–0.280	1.856
Left entorhinal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.055	1.000	–0.825	0.715
	ɛ4^–/BDNF^Met	–1.135	0.020	–2.148	–0.122
	ɛ4^–/BDNF^Val/Val	–1.202	0.004	–2.114	–0.290
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–1.079	0.007	–1.939	–0.219
	ɛ4^–/BDNF^Val/Val	–1.147	0.000	–1.871	–0.422
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	–0.067	1.000	–1.055	0.921
Right entorhinal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	0.166	0.989	–0.546	0.879
	ɛ4^–/BDNF^Met	–1.003	0.030	–1.940	–0.065
	ɛ4^–/BDNF^Val/Val	0.017	1.000	–0.827	0.861
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–1.169	0.001	–1.965	–0.373
	ɛ4^–/BDNF^Val/Val	–0.149	0.991	–0.820	0.521
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	1.020	0.021	0.105	1.934
Left inferior parietal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.153	0.998	–1.041	0.735
	ɛ4^–/BDNF^Met	–0.818	0.319	–1.987	0.351
	ɛ4^–/BDNF^Val/Val	–0.014	1.000	–1.066	1.038
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–0.665	0.368	–1.657	0.327
	ɛ4^–/BDNF^Val/Val	0.139	0.998	–0.697	0.974
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.804	0.311	–0.336	1.943
Right inferior parietal volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.459	0.655	–1.339	0.422
	ɛ4^–/BDNF^Met	–0.600	0.661	–1.759	0.559
	ɛ4^–/BDNF^Val/Val	–0.669	0.420	–1.713	0.374
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	–0.141	0.999	–1.125	0.843
	ɛ4^–/BDNF^Val/Val	–0.211	0.983	–1.039	0.618
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.669	0.420	–0.374	1.713
Left posterior cingulate volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.499	0.619	–1.424	0.426
	ɛ4^–/BDNF^Met	0.240	0.996	–0.977	1.458
	ɛ4^–/BDNF^Val/Val	–0.096	1.000	–1.192	1.000
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	0.739	0.296	–0.295	1.772
	ɛ4^–/BDNF^Val/Val	0.403	0.764	–0.468	1.274
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	–0.336	0.971	–1.523	0.851
Right posterior cingulate volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.293	0.950	–1.215	0.629
	ɛ4^–/BDNF^Met	0.487	0.861	–0.726	1.701
	ɛ4^–/BDNF^Val/Val	–0.025	1.000	–1.117	1.068
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	0.780	0.236	–0.250	1.811
	ɛ4^–/BDNF^Val/Val	0.268	0.956	–0.600	1.136
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	–0.512	0.815	–1.696	0.671
Left precuneus volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.400	0.809	–1.316	0.517
	ɛ4^–/BDNF^Met	–0.310	0.982	–1.517	0.896
	ɛ4^–/BDNF^Val/Val	–0.211	0.996	–1.297	0.875
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	0.089	1.000	–0.935	1.113
	ɛ4^–/BDNF^Val/Val	0.189	0.992	–0.674	1.052
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.100	1.000	–1.077	1.276
Right precuneus volume^a
ɛ4⁺/BDNF^Met	ɛ4⁺/BDNF^Val/Val	–0.296	0.941	–1.199	0.606
	ɛ4^–/BDNF^Met	–0.120	1.000	–1.308	1.068
	ɛ4^–/BDNF^Val/Val	0.031	1.000	–1.038	1.101
ɛ4⁺/BDNF^Val/Val	ɛ4^–/BDNF^Met	0.176	0.998	–0.832	1.185
	ɛ4^–/BDNF^Val/Val	0.328	0.882	–0.522	1.177
ɛ4^–/BDNF^Met	ɛ4^–/BDNF^Val/Val	0.151	1.000	–1.007	1.310

Analysis of covariance adjusted for age, gender and education. Mean differences are in standard deviation units. Values in bold indicate significant between-group differences (p < 0.05). ^aAdjusted for estimated total intracranial volume. ɛ4⁺/BDNF^Met, APOE ɛ4 and BDNF Met carriers’ group; ɛ4⁺/BDNF^Val/Val, APOE ɛ4 carriers and BDNF Met noncarriers’ group; ɛ4^–/BDNF^Met, APOE ɛ4 noncarriers and BDNF Met carriers’ group; ɛ4^–/BDNF^Val/Val, APOE ɛ4 and BDNF Met noncarriers’ group.