Table 1.
Measures of Neuronal Health and Cellular Activation
| Genotype | Age (months) | Holding Current (pA) | Input Resistance (MΩ) | AP Amplitude (mV) | # of APs During Imaging |
| WT Male | 1.5 | –125±65.1 | 91.3±15.2 | 4.5±2.3 | 70.2±3.0 |
| 4 | –241.7±16.6 | 48.7±2.6 | 7.7±1.5 | 70±0.6 | |
| 10 | –143.3±31.6 | 63.3±3.9 | 8.7±1.8 | 66.8±4.5 | |
| 5×FAD Male | 1.5 | –76.4±27.5 | 71.4±4.8 | 9.2±1.6 | 68.1±2.2 |
| 4 | –208.3±22.8 | 43.3±2.1 | 8.8±1.3 | 70±0.7 | |
| 10 | –156.3±36.1 | 61.0±4.7 | 7.8±1.9 | 73.8±1.2 | |
| WT Female | 1.5 | –120±48.1 | 76.5±10.7 | 10±2.1 | 68.7±0.3 |
| 4 | –120±27.6 | 54.6±4.6 | 9.1±1.8 | 66.8±4.3 | |
| 10 | –105±33.8 | 85.1±12.2 | 8.8±1.9 | 70.0±0 | |
| 5×FAD Female | 1.5 | –201.4±28.1 | 61.5±7.7 | 5.6±2.5 | 68.2±3.2 |
| 4 | –185.7±17.6 | 58.7±6.0 | 2.9±2.2 | 70.3±0.3 | |
| 10 | –84.3±40.1 | 80.0±4.9 | 6.5±1.6 | 70.7±0.3 | |
| Significance | – | p < 0.02 | p < 0.001 | n.s. | n.s. |
Neuronal health was compared across genotype, sex, and age. The amplitude of action potentials (AP) during AHP data acquisition and the number of APs during RSS while imaging were recorded. Holding current and input resistance reflect cell membrane “leakiness” and integrity. Holding current and input resistance at 4 months were both significantly elevated (p < 0.05). No changes were detected between groups on measures of AP amplitude or number of APs during imaging (p > 0.05).