Table 2.

Results and Statistical Analyses of Behavioral Data

Measure		Age (months)	F-value	p	Significance
Latency to Platform	Effect of Training	1.5	F (8,88)  = 11.26	p < 0.0001	Yes
		4	F (8,96)  = 4.896	p < 0.0001	Yes
		10	F (12,876)  = 68.14	p < 0.0001	Yes
	Effect of Genotype	1.5	F (1,11)  = 2.395	p = 0.15	No
		4	F (1,12)  = 0.008	p = 0.929	No
		10	F (1,73)  = 10.53	p = 0.0018	Yes
Time spent in target quadrant	Effect of Training	1.5	F (2,22)  = 12.21	p = 0.0003	Yes
		4	F (2,24)  = 0.666	p = 0.523	No
		10	F (3,228)  = 24.33	p < 0.0001	Yes
	Effect of Genotype	1.5	F (1,11)  = 0.006	p = 0.938	No
		4	F (1,12)  = 0.198	p = 0.663	No
		10	F (1,76)  = 12.03	p = 0.0009	Yes
Swim Speed	Effect of Genotype	1.5	F (5,6)  = 1.179	p = 0.022	Yes
		4	F (6,7)  = 4.374	p = 0.404	No
		10	F (36,36)  = 2.266	p = 0.8725	No

Latency to platform, time spent in the target quadrant, and swim speed were compared across genotype and age. Training significantly reduced the latency to platform across age (p < 0.0001); however, on measures of time spent in target quadrant, this was only seen in 1.5- and 10-month-old animals (p < 0.001). Compared to WT littermates, 5×FAD mice showed significant behavioral deficits by 10 months of age (p < 0.0018) and spent significantly less time in the target quadrant (p = 0.0009). Genotype significantly influenced swim speed at 1.5 months (p = 0.022), but not at 4 or 10 months.