Table 2.

Top enriched pathways and processes related to COVID-altered proteins

COVID	Ontology	Description	Count	%	Log10(P)
Altered	R-HSA-8953854	Metabolism of RNA	78	22.16	−51.2
	R-HSA-422475	Axon guidance	63	17.90	−40.6
	GO:0006412	Translation	66	18.75	−35.9
	GO:0000377	RNA splicing	44	12.50	−28.0
	GO:0045055	Regulated exocytosis	58	16.48	−26.7
	GO:0006457	Protein folding	33	9.38	−24.3
	R-HSA-1474244	Extracellular matrix organization	33	9.38	−20.6
	GO:0043687	Post-translational protein modification	35	9.94	−20.0
	GO:0071826	Ribonucleoprotein complex subunit organization	32	9.09	−19.7
	CORUM:5615	Emerin complex 52	13	3.69	−18.8
	GO:0010638	Positive regulation of organelle organization	40	11.36	−16.1
	GO:0042060	Wound healing	38	10.80	−15.6
	GO:0006913	Nucleocytoplasmic transport	30	8.52	−15.6
	R-HSA-114608	Platelet degranulation	19	6.27	−15.6
	R-HSA-5653656	Vesicle-mediated transport	40	11.36	−15.4
	GO:0097435	Supramolecular fiber organization	41	11.65	−15.1
	CORUM:1335	SNW1 complex	10	3.30	−15.1
	GO:0002181	Cytoplasmic translation	18	5.11	−15.1
	R-HSA-445355	Smooth Muscle Contraction	13	3.69	−14.9
	GO:0031647	Regulation of protein stability	27	7.67	−14.9
Up	R-HSA-72163	mRNA Splicing - Major Pathway	23	8.85	−18.8
	R-HSA-449147	Signaling by Interleukins	26	10.00	−12.6
	GO:0000904	Cell morphogenesis involved in differentiation	31	11.92	−11.3
Down	R-HSA-2262752	Cellular responses to stress	55	18.15	−34.5
	R-HSA-109581	Apoptosis	23	7.59	−17.5
	GO:0035966	Response to topologically incorrect protein	22	7.26	−15.0

Count: the number of DS-affinity proteins with membership in the given ontology term. %: percentage of DS-affinity proteins in the given ontology term.