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. 2021 Jan 26;21:117. doi: 10.1186/s12879-021-05806-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Varicella-zoster virus-specific humoral immune responses measured in a glycoprotein ELISA (gpELISA) assay before and at 6 weeks post-vaccination (a) and Log₂-fold increases in the gpELISA titers (c) for each study group. Varicella-zoster virus-specific cellular immune responses, measured using the enzyme-linked immunospot (ELISPOT) assay, before and at 6 weeks after vaccination (b) and Log₂-fold increases in spot-forming cell (sfc) counts (d) for each study group. The edges of the boxes represent the 25th and 75th percentiles, the horizontal lines inside the boxes are the median values, and the vertical whiskers represent the 2.5th and 97.5th percentiles (* p < 0.05, ** p < 0.01, *** p < 0.001)