Table 1.
Baseline characteristics of AIS patients without HT and with HT
| Variables | Total (n=570) | Non-HT (n=285) | HT (n=285) | P-value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age (years) | 68.9 ± 12.4 | 68.9 ± 12.3 | 68.9 ± 12.6 | 0.970 |
| Male, n (%) | 388 (68.1%) | 191 (67.0%) | 197 (69.1%) | 0.590 |
| Baseline SBP (mmHg) | 153.3 ± 23.1 | 158.0 ± 23.0 | 148.6 ± 22.3 | < 0.001 |
| Baseline DBP (mmHg) | 82.3 ± 13.8 | 82.1 ± 13.3 | 82.5 ± 14.3 | 0.732 |
| NIHSS on admission, median (IQR) | 5.0 (2.0–10.0) | 3.0 (1.0–5.0) | 9.0 (5.0–13.0) | < 0.001 |
| CTA, n (%) | 64 (11.2%) | 30 (10.5%) | 34 (11.9%) | 0.616 |
| Vascular risk factors, n (%) | ||||
| Current smoking | 210 (37.1%) | 118 (41.5%) | 92 (32.6%) | 0.028 |
| Current drinking | 228 (40.4%) | 141 (49.8%) | 87 (30.9%) | < 0.001 |
| Previous Stroke | 72 (12.6%) | 31 (10.9%) | 41 (14.4%) | 0.207 |
| Hypertension | 376 (66.0%) | 197 (69.1%) | 179 (62.8%) | 0.112 |
| Diabetes | 149 (26.1%) | 80 (28.1%) | 69 (24.2%) | 0.294 |
| CAD | 47 (8.3%) | 15 (5.3%) | 32 (11.3%) | 0.010 |
| Dyslipidemia | 37 (6.5%) | 17 (6.0%) | 20 (7.0%) | 0.610 |
| AF | 137 (24.0%) | 29 (10.2%) | 108 (37.9%) | < 0.001 |
| Hematological variables | ||||
| Leukocyte counts (×109/L) | 7.7 ± 2.8 | 6.8 ± 1.9 | 8.5 ± 3.3 | < 0.001 |
| Erythrocyte counts (×109/L) | 4.4 ± 0.6 | 4.4 ± 0.6 | 4.4 ± 0.6 | 0.836 |
| PLT (× 109/L), median (IQR) | 197.0 (162.0–235.0) | 205.0 (175.0–238.5) | 187.0 (148.5–231.0) | < 0.001 |
| MPV (fl) | 11.0 ± 1.4 | 11.2 ± 1.2 | 10.8 ± 1.4 | 0.011 |
| PT (s) | 13.7 ± 1.0 | 13.5 ± 1.0 | 13.9 ± 1.0 | < 0.001 |
| INR | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 | < 0.001 |
| FIB (g/L) | 3.8 ± 1.6 | 3.5 ± 1.0 | 4.1 ± 2.0 | < 0.001 |
| Stroke etiology, n (%) | < 0.001 | |||
| Atherosclerosis | 405 (75.6%) | 214 (84.9%) | 191 (67.3%) | |
| Cardioembolism | 109 (20.3%) | 20 (7.9%) | 89 (31.3%) | |
| Small vessel occlusion | 4 (0.7%) | 3 (1.2%) | 1 (0.4%) | |
| Other causes | 18 (3.3%) | 15 (6.0%) | 3 (1.1%) | |
| Treatment, n (%) | ||||
| Anticoagulant therapy | 114 (20%) | 28 (9.8%) | 86 (30.2%) | < 0.001 |
| Antiplatelet therapy | 419 (73.5%) | 256 (89.8%) | 163 (57.2%) | < 0.001 |
| Aspirin | 201 (35.3%) | 120 (42.1%) | 81 (28.4%) | 0.001 |
| Clopidogrel | 122 (21.4%) | 78 (27.4%) | 44 (15.4%) | < 0.001 |
| Double antiplatelet therapy | 96 (16.8%) | 58 (20.4%) | 38 (13.3%) | 0.025 |
Abbreviations: HT, hemorrhagic transformation; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institute of Health Stroke Scale; CTA, computered tomograhy angiography; CAD, coronary artery disease; AF, atrial fibrillation; PLT, platelet counts; MPV, mean platelet volume; PT, prothrombin time; INR, International Normalized Ratio; FIB, fibrinogen