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. 2021 Jan 26;21:76. doi: 10.1186/s12935-021-01776-4

Table 2.

Comparison of different injection approaches of AAV-based GBM gene therapy

Injection approaches Advantage Disadvantage References
Intratumoral injection Overcomes the BBB obstacle Transduces region limitation, Surgical risk [70, 71]
ICVinjection Good transduction for the brain parenchyma area close to the ventricle Instability of ICV injection, Only the hemibrain has good transduction [56, 74]
Systematic injection Extensive transduction throughout the brain Immune barrier, neutralizes antibodies in the blood [76, 87]