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. 2021 Jan 26;21:37. doi: 10.1186/s12876-021-01613-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effects of SCFAs on carbachol-evoked contractions of isolated mouse proximal column. a Original traces of carbachol-evoked contractions of proximal column before and after butyric acid (10 mM) incubation in control and in IBS model groups. Amplitude (b) and area under curve (AUC) (c) of carbachol-evoked contractions before (white column) and after incubation in sodium acetate (10 mM, dashed column), sodium propionate (10 mM, grey column) and butyric acid (10 mM, grey dashed column) in the control and IBS model groups. *p < 0.05 compared to carbachol effect before SCFAs application; ^#p < 0.05 compared to carbachol-evoked contractions in the control group