Table 3.
Contractile activity of mouse proximal colon during acute SCFAs application in IBS model group
| Concentration of SCFAs (mM) | Tonic tension (g) | Amplitude (g) | Frequency (min−1) |
|---|---|---|---|
| Sodium acetate | |||
| Initial value | 0.879 ± 0.01 | 0.884 ± 0.058 | 3.204 ± 0.117 |
| 0.5 | 0.85 ± 0.009 | 0.893 ± 0.024 | 2.694 ± 0.098* |
| 1 | 0.791 ± 0.009* | 0.801 ± 0.026* | 2.643 ± 0.097* |
| 5 | 0.864 ± 0.009* | 0.783 ± 0.028*# | 2.469 ± 0.121* |
| 10 | 0.723 ± 0.008* | 0.693 ± 0.029*# | 1.857 ± 0.092*# |
| 30 | 0.648 ± 0.007* | 0.532 ± 0.034*# | 1.143 ± 0.13*# |
| Sodium propionate | |||
| Initial value | 0.815 ± 0.021 | 0.848 ± 0.057 | 2.636 ± 0.102 |
| 0.5 | 0.814 ± 0.021 | 0.901 ± 0.026 | 2.33 ± 0.096 |
| 1 | 0.767 ± 0.02 | 0.795 ± 0.026 | 1.773 ± 0.08* |
| 5 | 0.727 ± 0.019* | 0.77 ± 0.029 | 1.417 ± 0.087* |
| 10 | 0.698 ± 0.018*# | 0.633 ± 0.027*# | 1.045 ± 0.076* |
| 30 | 0.516 ± 0.019*# | 0.58 ± 0.029*# | 0.693 ± 0.098*# |
| Butyric acid | |||
| Initial value | 0.855 ± 0.023 | 0.857 ± 0.046 | 2.512 ± 0.086 |
| 0.5 | 0.832 ± 0.021 | 0.873 ± 0.025 | 2.427 ± 0.107 |
| 1 | 0.811 ± 0.02 | 0.787 ± 0.023# | 1.878 ± 0.143*# |
| 5 | 0.757 ± 0.025 | 0.724 ± 0.026# | 1.463 ± 0.105*# |
| 10 | 0.772 ± 0.018*# | 0.652 ± 0.032*# | 1.203 ± 0.133*# |
| 30 | 0.714 ± 0.021*# | 0.501 ± 0.033*# | 1.069 ± 0.147*# |
*p < 0.05 compared to the initial value; #p < 0.05 compared to the control group