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Precocious centriole disengagement in Cep57/Cep57L1-depleted cells. HeLa-GFP-centrin1 (green) cells were treated with siCep57 and siCep57L1 in the presence of SiR-DNA (200 nM, red). 25 × 1.2–µm z-stacks were acquired every 10 min at 40× magnification. Image frames shown are maximum-intensity projections at each time point.
